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KMID : 0361520100210030150
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Korean Journal of Psychopharmacology
2010 Volume.21 No. 3 p.150 ~ p.155
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Phenomenology of Delirium in Cancer Patients and Its Association with Sedative-Hypnotics
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Kim Yong-Hwan
Kim Sung-Wan
Jang Ji-Eun
Kim Seon-Young
Shin Il-Seon
Kim Jae-Min
Yoon Jin-Sang
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Abstract
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Objective : This study explored the phenomenology of delirium in cancer patients, and evaluated the severity of delirium according to the cancer treatment method and the use of sedative-hypnotics, including zolpidem.
Methods : This was a retrospective chart review study. Cancer patients with delirium, who were referred to the Department of Psychiatry at a National University hospital, were included in the analysis. In all subjects, the severity of delirium was assessed using the Delirium Rating Scale-Revised-98 (DRS-R-98).
Results : The analysis included 112 patients with delirium. Among the neuropsychiatric and behavioral symptoms, the most frequent ones were sleep-wake cycle disturbance (100.0%) and perceptual disturbances and hallucinations (95.5%). Among the cognitive symptoms, inattention (98.2%) was the most frequent. The older the patients were, the higher the DRS-R-98 total scores were. There was no significant difference in the DRS-R-98 scores among cancer treatment methods (operation, chemotherapy, or radiation therapy). However, the total DRS-R-98 scores in the zolpidem use group were higher than in control group, and the difference was significant after adjusting for age, sex, and type of cancer treatment.
Conclusion : Sleep-wake cycle disturbance, inattention, and perceptual disturbances were the most common delirium symptoms in cancer patients. The severity of delirium in patients taking zolpidem was significantly greater.
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KEYWORD
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Cancer, Delirium, DRS-R-98, Zolpidem, Benzodiazepine
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